What is Angel yeast beta glucan? "Super Ganoderma lucidum" in new food raw materials

Data shows that the global market for immune enhancing foods will continue to grow, with an expected value of over $1.3 trillion by 2026 and a compound annual growth rate of 7.6%. In China, consumers' increasing emphasis on health has driven the development of a huge market for immune related products.

In 2023, among the domestically approved health foods in China, the number of health products focused on immune enhancement is the highest, accounting for nearly 42%. In the past two years, traditional natural herbal ingredients such as Ganoderma lucidum and wolfberry have gradually been accepted by modern consumers, and yeast β - glucan, known as the "super Ganoderma lucidum", and various emerging immune enhancing ingredients have also seen significant growth.

As early as the mid to late last century, scientists discovered the important value of yeast β - glucan in enhancing immunity. Angel Yeast Co., Ltd. has been deeply involved in yeast biotechnology and has collaborated with numerous scientific universities for many years to explore the greater application value of yeast β - glucan. Research has found that yeast β - glucan not only has nutritional value in enhancing immunity, but also has a positive impact on cognitive impairment in the elderly and controlling obesity caused by a high-fat diet.

Nowadays, in the food industry, Angel Yeast's patented yeast β - glucan has been applied in dairy products, meat products, functional beverages, functional foods, and health products.

This article will introduce the definition of yeast β - glucan, the advantages of Angel yeast β - glucan, application cases, and relevant laws and regulations, taking you to understand Angel yeast β - glucan together. Welcome to learn more about this article!

catalogue

1、 Definition of yeast β - glucan

2、 The role and related research of yeast β - glucan

3、 Application Cases

4、 Regulations and standards related to yeast β - glucan

5、 Reference source

1、 Definition of yeast β - glucan

（1） Yeast β - glucan

β - glucan is widely present in various organisms in nature, and different sources of glucan have structural differences, physiological activities, and immune regulatory abilities. Grains such as oats and barley, which are sources of pectin, mainly help reduce cholesterol and lower blood sugar levels; 3. Some sources of algae fermentation, such as pectin, can help enhance immunity. four

Yeast derived β - glucan is a pure natural active ingredient present in the inner layer of yeast cell walls. In the 1940s and 1950s, scientists first discovered yeast β - glucan in bread yeast, which has the ability to enhance immunity. Compared to other sources of β - glucan, yeast β - glucan has higher immune boosting activity. five

Yeast β - glucan has been approved by the Ministry of Health as a new resource food and can be added to various foods such as dairy products, functional beverages, baked goods, candies, etc. In 2012, the Ministry of Health issued Announcement No. 6, which expanded the use of yeast β - glucan to include formula milk powder for older infants. six

β - glucan in yeast cell wall

（2） Angel yeast β - glucan

Angel Yeast Co., Ltd. has been focusing on yeast biotechnology for many years, specializing in yeast fermentation nutrition. Its research and development of Bettcan ® Yeast β - glucan is a pure natural active ingredient present in the inner layer of yeast cell wall, consisting of β -1,3-D-glucan as the main chain and β -1,6-D-glucan as the branch chain.

The unique β -1,3/1,6 molecular structure of yeast β - glucan is the key to its enhanced immune function, and also endows it with multiple health benefits such as assisting in improving radiation damage and regulating gut microbiota, which have been scientifically verified by research. seven

Yeast β-glucan

2、 The role and related research of yeast β - glucan

Angel yeast has made multiple contributions and breakthroughs in the research field of yeast β - glucan. It has collaborated with universities to explore new directions for yeast β - glucan and conducted multiple clinical trials.

（1） Immune enhancement improves upper respiratory tract infections

In 2022, Angel Yeast Co., Ltd. conducted a double-blind randomized controlled study in Australia on yeast β - glucan targeting upper respiratory problems. During a 3-month experimental period, it was found that taking 200mg yeast β - glucan daily for 12 weeks helped reduce the severity of sore throat during colds and improve sleep quality in participants. Meanwhile, this study also found that yeast β - glucan helps reduce rest days, with the yeast β - glucan group having only 0.3 days of rest compared to the placebo group's average rest time of 0.7 days.

Effect of yeast β - glucan on incidence rate and severity of upper respiratory tract infection

In addition, a randomized, double-blind, controlled trial was conducted on children aged 8-12 to investigate the effectiveness of yeast β - glucan in addressing upper respiratory problems. Research has found that short-term consumption of naturally sourced yeast β - glucan can increase the levels of albumin and lysozyme in saliva of children with respiratory problems, and improve the mucosal immune function of children with chronic respiratory problems. eight

（2） Balance intestinal health and combat metabolic obesity

Meanwhile, Angel Yeast is also collaborating with university research teams to explore more functional directions of yeast β - glucan.

In 2021, Angel Yeast and a team from Nanjing Agricultural University found that yeast β - glucan can improve the occurrence of metabolic syndrome (MS) in mice by regulating gut microbiota, including improving body weight, fat accumulation, and liver steatosis. This means that yeast β - glucan can serve as a prebiotic for preventing MS and regulating gut microbiota. nine

In 2022, the School of Public Health at Huazhong University of Science and Technology found that yeast β - glucan can resist weight gain, dyslipidemia, and systemic inflammation in rats. In addition, long-term supplementation of yeast β - glucan can restore the intestinal ecological imbalance and changes in short chain fatty acid and lipopolysaccharide levels caused by high-fat diet, providing a new nutritional strategy for reducing obesity. 10 11

（3） Regulating gut microbiota to prevent senile dementia

Research has shown that gut microbiota can affect the gut brain axis, which in turn affects cognitive abilities. In 2020, a team from the School of Public Health at Huazhong University of Science and Technology found that long-term supplementation of yeast β - glucan in mice resulted in significant changes in gut microbiota composition. In addition, yeast β - glucan is also believed to be closely related to the formation of Alzheimer's disease (AD). Yeast β - glucan may improve cognitive dysfunction in rats through the gut brain axis, alleviate inflammation, and improve AD like symptoms, and the effect of large molecule yeast β - glucan is better than that of small molecule yeast β - glucan. thirteen

Escape time and distance of rats

Note: A β is a rat model of Alzheimer's disease; S - β - Glu: Small molecule yeast β - glucan; M - β - Glu: Large molecule yeast β - glucan

Image source: 13 research papers

（4） Assist in improving the damage caused by radiation

There are many sources of radiation in people's lives, such as water and food contaminated with radiation. Vegetables, fruits, and animal livers containing vitamins A, C, and E in daily diet are good anti radiation nutrients and foods. fourteen

In addition, studies have shown that yeast β - glucan can assist in improving radiation-induced damage. In the experiment, the researchers administered yeast β - glucan to the test mice by gavage, and after 15 days of continuous gavage, they were exposed to three different types of radiation. The results showed that yeast β - glucan could reduce micronuclei in bone marrow cells and increase SOD activity in red blood cells of irradiated mice, indicating that oral yeast polysaccharides have an auxiliary protective effect against radiation. fifteen

Changes in related indicators of yeast β - glucan after (60) Co - γ - ray irradiation in mice
4、 Regulations and standards related to yeast β - glucan

In 2019, yeast derived β - glucan was approved by the US FDA as a recognized safe food additive (GRAS).

In 2010, yeast β - glucan was approved by the Ministry of Health as a new resource food, with a consumption limit of no more than 250mg/day, and the scope of application does not include infant and toddler food.

In 2012, the Ministry of Health approved yeast β - glucan as a nutritional fortifier for use in infant formula powder and children's milk powder, with a dosage of 0.21-0.67g/kg.

Angel Yeast Co., Ltd. participated in the development of industry standards for yeast β - glucan, as well as in the development of national standards for food safety, yeast β - glucan, and determination of yeast β - glucan content in food. It is a participant in the development of various national standards for yeast and yeast derivatives.

5、 Reference source

1. The Business Research Company (2023), "2022 Global Market Report on Immune Enhancing Foods"

2 Jian Tian Xing (2024), "2023 Annual Inventory | Health Food Registration Approval Number Reaches New High, Review Accelerates Across the Board

3 China Health Management (2023), "Nutrition Encyclopedia - β - glucan"

4 Open Veterinary Journal (2022), Inhibition of African swine fever virus replication by β-glucan

5 Di Luzio NR, Riggi SJ (1970), The effects of laminarin, sulfated glucan and oligosaccharides of glucan on reticuloendothelial activity. J Reticuloendothel Soc 8(5): 465-473

Angel Yeast (2024), "Yeast β - Glucan - Polysaccharide as a New Food Ingredient"

Angel Yeast (2024), "Natural Immune Regulator 'Yeast β - Glucan', Activating the Body's Intrinsic Defense"

8 Vaclav V, Josef R, Vladimir S, et al. (2014), Clinical trials of yeast-derived β-(1,3) glucan in children: effects on innate immunity.Ann Transl Med.2014; 2(2):15

9 Guijie Chen, Dan Chen (2021), Improvement of Metabolic Syndrome in High-Fat Diet-Induced Mice by Yeast β-Glucan Is Linked to Inhibited Proliferation of Lactobacillus and Lactococcus in Gut Microbiota. J. Agric. Food Chem. 2021, 69, 27, 7581–7592.

10 National Institutes of Health (2022), Insoluble yeast β-glucan attenuates high-fat diet-induced obesity by regulating gut microbiota and its metabolites.

11 Li X, Wu J. (2022), Yeast mannoproteins are expected to bea novel potential functional food for attenuation of obesity and modulation of gut microbiota. Front. Nutr. 9:1019344

12 J.F. Cryan, T.G. Dinan (2012), Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour Nat. Rev. Neurosci. 13 701–712

13 National Institutes of Health (2020), Yeast β-glucan alleviates cognitive deficit by regulating gut microbiota and metabolites in Aβ1–42-induced AD-like mice . International Journal of Biological Macromolecules.

14 New Nutrients (2023), "What can yeast β - glucan do during the nuclear radiation crisis

15 Zhang Yan, Xia Changhong, Zhu Yamin et al. (2010), "Study on the Anti Radiation Effect of Yeast Glucan", Geriatric Nutrition Branch of the Chinese Nutrition Society