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D-Tetrandrine
1. D-Tetrandrine: A Potent Natural Alkaloid for Modern Therapeutics by Shaanxi Zhonghong Investment Technology
Introduction
Shaanxi Zhonghong Investment Technology Co., Ltd. is a globally acclaimed high-tech enterprise specializing in the extraction, purification, and commercialization of bioactive plant-derived compounds. With expertise spanning chemistry, materials, and life sciences, the company produces D-Tetrandrine—a bioactive alkaloid sourced from Stephania tetrandra (Chinese moonseed). Renowned for its anti-inflammatory, anti-tumor, and immunomodulatory properties, this pharmaceutical-grade ingredient is trusted by researchers, drug manufacturers, and healthcare providers worldwide for its purity, efficacy, and compliance with international standards.
2. Scientific Innovation & Regulatory Excellence
Cutting-Edge R&D
Academic Collaborations: Partners with 5 leading universities to refine extraction protocols and validate therapeutic applications.
Proprietary Technology: 20+ patents and a proprietary compound library ensure unmatched quality and batch consistency.
Advanced Equipment: Utilizes HPLC, NMR, and CO2 supercritical extraction systems, achieving ≥98% purity—exceeding pharmacopeial benchmarks.
Global Network
Supplies pharmaceutical-grade D-Tetrandrine to oncology research labs, drug developers, and clinical institutions across 30+ countries in Asia, Europe, and the Americas.
3. D-Tetrandrine: Health Benefits & Clinical Applications
Therapeutic Benefits
Anti-Cancer Potential: Inhibits tumor cell proliferation and induces apoptosis in preclinical studies.
Anti-Inflammatory Action: Suppresses NF-κB signaling, reducing chronic inflammation in autoimmune diseases.
Cardiovascular Protection: Lowers blood pressure and prevents arterial calcification.
Antiviral Activity: Shows efficacy against hepatitis B and HIV in experimental models.
Targeted Applications
Oncology: Adjuvant therapy for lung, liver, and breast cancer research.
Rheumatology: Investigated for rheumatoid arthritis and lupus treatment.
Virology: Explored in antiviral drug development.
4. Usage Guidelines & Safety Precautions
Applications
Pharmaceuticals: Active ingredient in injectables, tablets, or capsules.
Research: Used in in vitro and in vivo studies for mechanistic insights.
Dosage
Preclinical Studies: 10–50 mg/kg body weight (animal models).
Human Trials: Under strict medical supervision; dosage varies by protocol.
Critical Safety Notes
Contraindications: Avoid during pregnancy, breastfeeding, or in patients with liver/kidney impairment.
Side Effects: Potential hepatotoxicity at high doses; monitor liver enzymes.
Storage: Store at 2–8°C in airtight, light-resistant containers.
5. Product Specifications & Quality Assurance
Chemical Profile
CAS No.: 518-34-3
Molecular Formula: C₃₈H₄₂N₂O₆
Molecular Weight: 622.75 g/mol
EINECS: 610-872-4
Purity: ≥98% (HPLC-verified).
Safety & Compliance Standards
| Parameter | Standard | Testing Method |
|---|---|---|
| Pesticide Residues | ≤0.01 ppm (USP/EP compliant) | GC-MS |
| Heavy Metals | Pb ≤1 ppm, As ≤0.5 ppm, Cd ≤0.2 ppm | ICP-MS |
| Microbial Limits | Total plate count ≤100 CFU/g | USP <61> |
| Residual Solvents | Meets ICH Q3C Class 2 limits | HPLC |
6. Sustainable Production & Certifications
GMP Compliance: Manufactured in ISO 9001/ISO 14001-certified facilities.
Certifications: USP, EP, FDA DMF, and WHO PQ listed.
Customization: Available as bulk powder, lyophilized form, or sterile solutions.
7. Applications Across Industries
Pharmaceuticals: Core component in anti-cancer and anti-inflammatory drug formulations.
Academic Research: Used in molecular biology and pharmacology studies.
Biotechnology: Investigated for targeted drug delivery systems.
8. Packaging, Logistics & Support
Packaging: Amber glass vials (1 mg to 100 g) or pharmaceutical-grade containers.
Shipping: Temperature-controlled global logistics via DHL/FedEx.
Samples: Available for qualified research and industry clients.
9. Why Partner with Shaanxi Zhonghong?
Unmatched Purity: HPLC-verified ≥98% purity ensures research and therapeutic efficacy.
Regulatory Expertise: Full documentation (COA, MSDS, DMF) for global compliance.
Trusted Supplier: Preferred partner for leading oncology and immunology research hubs.
10. FAQs
Q1: Is D-Tetrandrine approved for clinical use?
Currently under clinical investigation; not yet FDA-approved for therapeutic use.
Q2: Can it be used in combination therapies?
Yes, but only under controlled research or clinical trial settings.
Q3: What is the shelf life?
24 months when stored in unopened, recommended conditions.
11. Conclusion
Shaanxi Zhonghong’s D-Tetrandrine represents the pinnacle of natural alkaloid research, offering groundbreaking potential in oncology, immunology, and virology. Backed by rigorous quality controls, global certifications, and sustainable practices, it empowers scientists and pharmaceutical innovators to advance cutting-edge therapeutic solutions.
References:
United States Pharmacopeia (USP)
European Pharmacopoeia (Ph. Eur.)
Journal of Natural Products (ACS Publications).
