Mink powder Leech extract

Application and synthesis method of leech powder
brief introduction
Hirudo is an insect drug for breaking blood and removing blood stasis. According to the theory of traditional Chinese medicine that blood stasis will occur after a long illness and the collateral principle of people with a long illness, hirudo powder has been used clinically to treat hyperlipidemia, acute and chronic nephritis, nephrotic syndrome, hypertensive nephropathy, diabetes nephropathy, lupus nephritis, and has a good effect. There are different records in ancient and modern times about whether leech powder is toxic But most clinical reports in modern times claim that it is beneficial and non-toxic as a good medicine, and also seems to have no drawbacks of consuming or breaking gas. However, patients with allergies and severe digestive system problems should use caution.
effect
Leech powder has the function of breaking blood stasis and promoting menstrual flow. In clinical practice, leech powder can be used to regulate related diseases in the human body, especially leech powder has strong interference with blood, which can prolong blood clotting time, lower blood lipids, terminate pregnancy, and even treat malignant diseases such as tumors. Leech powder has excellent effects on breaking blood and promoting menstruation, making it suitable for treating stubborn amenorrhea and related blood stasis diseases in women. Middle aged and elderly people can take leech powder orally to prevent the occurrence of cerebral thrombosis, and it also has an auxiliary therapeutic effect on hemiplegia caused by post-stroke sequelae.
Functional indications
The efficacy and function of leeches are not only that. Leeches are a kind of valuable Chinese medicinal materials. Due to the particularity of leeches, the medicinal effect of leeches is anti coagulation, that is, hirudin, which has good clinical effects on stroke, paralysis, swelling and pain and other diseases. Moreover, if hirudin is used in some surgical procedures, it can maintain smooth blood flow in the veins, which has a certain effect on postoperative excessive bleeding.

In addition, the efficacy and function of leeches are also manifested in their ability to prevent blood clotting, and many scientists have begun to use leeches to develop drugs for other species, achieving good results. The artificial breeding of leeches has also reached a certain scale.

Effect and Function
1. Hangxue coagulation effect. Hirudin has the effect of preventing blood clotting, therefore it has an anti thrombotic effect

2. Thrombolytic effect. Hirudin has antiplatelet aggregation and thrombolytic effects on thrombosis caused by thrombin. Hirudin is a methanol extract that activates the fibrinolytic system both in vitro and in vivo; The saliva gland secretion of leeches has a strong antithrombotic effect after intravenous injection into rats.

3. Hang platelet function. Hirudin can inhibit the binding of thrombin to platelets, promote the dissociation of thrombin from platelets, and inhibit the release of platelets stimulated by thrombin and the response induced by thrombin.

4. The impact on hemorheology. Administering 0.45g/kg of leech extract to animals can reduce blood viscosity and shorten the electrophoresis time of red blood cells. Administration of leech decoction by gavage can also reduce the whole blood viscosity, plasma viscosity, hematocrit, and fibrinogen content in rats with abnormal blood rheology.

5. Hypolipidemic effect. For rabbits with feeding induced hyperlipidemia, daily administration of 1 gram of leech powder can reduce cholesterol and triglyceride levels in the blood, as well as alleviate aortic and coronary artery lesions compared to the control group. Plaque regression is significant, and collagen fiber growth and cholesterol crystal reduction can be observed.

6. Impact on cardiovascular function. Injecting hirudin 30g/kg intraperitoneally can significantly increase the ability of mouse myocardium to uptake 86Rb, indicating an increase in myocardial nutritional blood flow.

7. Termination of pregnancy effect. The wide bodied golden leech has a terminating effect on early, middle, and late pregnancy in mice. Using leech decoction at a dose of 2.5-3 g/kg, subcutaneous injection of the above dose twice on the first, sixth, or tenth day of pregnancy has a significant effect on terminating pregnancy in mice.

8. The impact on experimental cerebral hematoma and subcutaneous hematoma. Leech extract has a promoting effect on the absorption of experimental intracerebral hemorrhage in rabbits. Experiments have shown that leeches can promote the absorption of cerebral and subcutaneous hematomas, reduce peripheral inflammatory reactions and edema, alleviate intracranial pressure elevation, improve local blood circulation, protect brain tissue from necrosis, and promote the recovery of neurological function.

9. The impact on experimental kidney damage. Using 30% leech solution at a dose of 15ml/kg, administered orally twice, has a significant preventive and therapeutic effect on the initial acute tubular necrosis caused by intramuscular injection of glycerol in rats, resulting in significantly lower levels of blood urea nitrogen and creatinine compared to the control group. The morphological changes in renal tissue have significantly improved. Its mechanism of action may be related to improving blood rheology and hypercoagulability, thereby improving renal blood circulation.

10. Other functions. Leeches also have inhibitory effects on decidua tumors. Low concentration leech solution has a significant contractile effect on the isolated uterus of rabbits. Hirudin can also inhibit thrombin induced fibroblast proliferation and the stimulating effect of thrombin on endothelial cells.