Yeast β - glucan test shows that it is very beneficial to human health and is known as "super Ganoderma lucidum" and "immune gold"

The development and research of β - glucan is now very hot!

β -glucan is a homopolymer of glucose, which exists in microorganisms, plants and animals. Glucose units of β - glucans from different sources are connected together in different ways to form bioactive polymers. In the 1940s, pillemer and Ecker found an active substance in yeast cells, which has the effect of immune stimulation. It was not until around 1960 that di LUZIO and Riggi determined that this active substance was β - 1,3-glucan. Many experimental studies in recent years have shown that β - glucan, which is very beneficial to human physiological functions, can significantly reduce blood glucose, blood lipids, and improve immunity, so the development and research of β - glucan is very hot.

The highest biological activity is yeast β - glucan!

Beta glucan

The most bioactive β - glucan is yeast β - glucan. Yeast is an important food industry microorganism. Glucan, protein and mannan are the innermost to outermost layers of yeast cell wall, respectively. The glucan located in the innermost layer is a homogeneous active polysaccharide. β - glucan in yeast is composed of a linear skeleton composed of D-glucose linked by β - 1 and 3 bonds and branches and backbones connected by β - 1 and 6 bonds. Compared with general fungi, yeast β - glucan has longer branches. Yeast β - glucan has great commercial value in many industries, such as food, medicine, cosmetics and aquaculture.

Super "cell molecule" immune regulation, balance immunity!

The most basic function of β - glucan is immune regulation. Experimental studies in vivo and in vitro have found that β - glucan can stimulate the innate immune system, thereby greatly improving the ability to resist bacteria, fungi and viruses. β - glucan can activate T cells, macrophages and natural killer cells, but also stimulate the differentiation and activation of T lymphocytes, affect and activate the changes of pathway complement, and finally achieve the effect of enhancing the body's cellular and humoral immunity. It is known as "super Ganoderma lucidum" and "immune gold".

Anticancer, anti-inflammatory, antioxidant, anti radiation, antithrombotic!

Reduce blood sugar, blood lipid, regulate intestinal tract, and promote wound healing!

1. improve body immunity and anti infection

Yeast β - glucan has immunoregulatory effects and can bind with macrophages in animals to activate macrophages; It can activate T lymphocytes, B lymphocytes, macrophages, natural killer cells (NK) and other immune enhancers; It can secrete some cytokines that activate immune cells, thereby enhancing the function of animal immune system, so it is used as an immunostimulant; It can also activate neutrophils and phagocytes in gastrointestinal tissues, thereby further activating and affecting the "immune neuroendocrine" regulatory network, enhancing its anti infection, anti stress and cell adaptive protection capabilities.

2. anti tumor

Tumor immunotherapy is an important adjuvant therapy after tumor surgery, chemotherapy and radiotherapy, which has the advantages of strong specificity, wide anti-tumor spectrum, and mild toxic and side effects. In recent decades, as a natural biological effect regulator, β - glucan has been widely used in the research of tumor immunotherapy. Yeast β - glucan has anti-tumor and anti infection effects. Studies have shown that this effect is achieved by stimulating the immune system and improving the body's disease resistance, rather than directly affecting the toxic cells of tumors. High dose of yeast β - glucan can significantly improve the activity of macrophages and enhance the humoral immune function. Yeast β - glucan can induce macrophages to produce interleukin-2 (IL-2) and nitric oxide (no), so as to improve immunity and have strong inhibitory activity on the proliferation of cancer cells.

3. anti radiation, promote hematopoiesis

Anti radiation effect. The anti radiation effect of dextran is the result of promoting hematopoietic function. Yeast β - glucan can enhance the generative activity of blood cells, including the generation of granulocytes, mononuclear leukocytes and red blood cells, leading to better recovery from lethal doses of radiation.

4. reduce cholesterol and blood lipids

Because animals generally cannot synthesize β - glucanase by themselves, the β - glucan ingested cannot be decomposed and can only be passively absorbed in the form of nutritional fibers, which have the functional effects of reducing blood lipids and cholesterol. The absorption of β - glucan can increase the intestinal viscosity, thus reducing the body's absorption of cholesterol and promoting excretion; The special spatial structure of β - glucan can promote the release of lipoproteins and fatty acids, and decompose macromolecular lipids in blood into small molecules, which is conducive to blood clarification and cholesterol reduction. The study found that when 15 obese men with high cholesterol were given yeast dextran, it was found that the total cholesterol content in the blood of the patients decreased by 8% at the seventh week while keeping their weight unchanged. It is reported that β - glucan can adsorb cholesterol and bile acids through active groups on the surface to reduce the reabsorption of these substances in the liver, thereby reducing the cholesterol content in animals.

5. regulating blood glucose

When β - glucan enters the mouth, it will start to absorb water and expand. The water-soluble β - glucan will increase the viscosity of food and slow down the gastric emptying, thus increasing the sense of satisfaction when eating and the feeling of satiety after eating. β - glucan can regulate blood glucose by increasing chyme viscosity, affecting carbohydrate absorption, protecting pancreatic β - cells, repairing their lesions, and improving their functional properties.

6. oxidation resistance

Yeast β - glucan has a strong antioxidant effect. It can eliminate free radicals in the body, improve the activity of antioxidant enzymes, prevent the damage of peroxides and reactive oxygen species to the body, and improve the antioxidant capacity of the body. It is reported that water-soluble yeast glucan can increase SOD activity in serum, and it is positively correlated with the dose. Yeast β - glucan can reduce the content of malondialdehyde in the liver and increase the activity of glutathione peroxidase.

7. improve gastrointestinal function and affect intestinal flora

Because there is no enzyme that degrades β - glucan in human body, they have the function of natural nutrient fiber. Studies have shown that a high fiber diet can reduce cholesterol and reduce the incidence of chronic diseases such as arthritis and heart disease. When β - glucan enters the mouth, it will start to absorb water and expand. Water soluble β - glucan will increase the viscosity of food and slow down the speed of gastric emptying, thus increasing the sense of satisfaction during meals and satiety after meals. β - glucan can reduce the number of harmful bacteria in the intestine by adsorbing pathogenic bacteria such as Salmonella and Escherichia coli; It can promote the proliferation of gram positive beneficial active bacteria in the intestine and inhibit the proliferation of gram negative saprophytic bacteria; Improve the secretion of secretory IgA on the intestinal surface, thereby improving gastrointestinal function and regulating the balance of intestinal flora.

8. promote wound healing

The essence of wound repair is the repair of homeostasis, which is a very complex physiological process. Under normal circumstances, the repair of trauma requires the interaction of macrophages, fibroblasts, keratinocytes, wound growth factors, matrix proteins and matrix repair enzymes between cells with different phenotypes. Relevant literature also shows that local or systemic β - glucan administration can accelerate wound healing, and its mechanism is to increase the infiltration of macrophages into the wound, thus promoting the growth of granulation and collagen deposition, while strengthening the tensile strength of the wound.

9. anticoagulant effect

After the experimental study, it was found that the decisive factor of β - glucan anticoagulation was the basic structure of polysaccharide and the sulfation mode. The mode of action of β - glucan is different from that of heparin. They rely on their own unique structure to regulate antithrombin AT-III, inhibit the activity of coagulation factors IIA and Xa, and achieve specific interference with different stages of the coagulation process.

FDA listed as food safety raw materials!

China approved as a new resource food!

Yeast glucan has a variety of physiological activities due to its special structure, and has been listed in Gras (generally considered safe) by FDA in the United States. As a food raw material, it is widely used in various foods. In China, in 2010, the Ministry of health of the People'sRepublic ofChina approved yeast glucan as a new resource food, so that it can be used in all kinds of food. It is allowed to produce and operate as ordinary food.

Dosage recommendation: take no more than 250 mg of yeast β - glucan per day.

References:

Research Progress on nutrition of yeast β - glucan

Research progress and application of yeast β - glucan

Research progress of β - glucan in anti-tumor immune response

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