Podofilox
Podofilox

Podofilox

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English namePodophyllotoxin English synonyms Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one,5,8,8a,9-tetrahydro-9-hydr oxy-5-(3,4,5-trimethoxyphenyl)-,(5R,5aR,8aR,9R)-;Podophyllotoxin,98%;(5R)-5,8,8aβ,9- Tetrahydro-9β-hydroxy-5-(3,4,5-trimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aαH)-one ;Podophyllotoxin,95%;trimethoxyphenyl)-furo(3',4':6,7)naphtho[2,3-d ]-1,3-dioxol-6(5aH)-one;PODOPHYLLIN(RG);5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethox yphenyl)-furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5ah)-one;(5R,5AR,8AR,9R)-9-HYDROXY -5- (3,4,5-TRIMETHOXY-PHENYL)-5,8,8A,9-TETRAHYDRO-5AH-FURO[3',4':6,7]NAPHTHO[2,3-D][1,3]DIOXOL -6-ONE
CAS No. 518-28-5
Molecular formula C22H22O8
Molecular weight 414.41
EINECS No. 208-250-4
Use: Inhibits microtubule assembly; anti-tumor.
Clinically used for acute monocytic and acute myelomonocytic Leukemia, acute myeloid leukemia, chronic eosinophilic leukemia, small cell lung cancer, non-Hodgkin's malignant lymphoma, testicular cancer, etc.
Product Description

1. Podofilox (Podophyllotoxin): Precision in Dermatological Care by Shaanxi Zhonghong Investment Technology

Introduction
Shaanxi Zhonghong Investment Technology Co., Ltd. is a leading high-tech enterprise specializing in the extraction, purification, and global distribution of bioactive plant-derived compounds. With expertise in chemistry, materials, and life sciences, the company produces Podofilox (Podophyllotoxin)—a potent antiviral agent sourced from the roots of Podophyllum plants. Renowned for its efficacy in treating skin conditions, this pharmaceutical-grade ingredient is trusted by global healthcare and dermatology industries for its purity, safety, and compliance with international standards.


2. Scientific Excellence & Regulatory Compliance

Innovative R&D

Academic Collaborations: Partners with 5 top-tier universities to optimize extraction methods and validate therapeutic applications.

Proprietary Technology: 20+ patents and a proprietary compound library ensure superior quality and consistency.

Advanced Equipment: Utilizes HPLC, GC-MS, and NMR systems to achieve ≥98% purity, exceeding pharmacopeial standards.

Global Reach
Supplies pharmaceutical-grade Podofilox to drug manufacturers, dermatology clinics, and research institutions across 30+ countries in Asia, Europe, and the Americas.


3. Podofilox: Therapeutic Benefits & Applications

Health Benefits

Antiviral Action: Effectively treats genital warts (caused by HPV) by inhibiting viral cell division.

Precision Treatment: Targets abnormal tissue growth while minimizing damage to healthy skin.

Cost-Effective: Reduces the need for invasive procedures like surgery or cryotherapy.

Primary Use Cases

Dermatology: Topical solution for external genital and perianal warts.

Pharmaceuticals: Active ingredient in FDA/EMA-approved antiviral formulations.


4. Usage Guidelines & Safety Precautions

Applications

Topical Use Only: Applied directly to warts using a specialized applicator.

Dosage

Adults: Apply 0.5% solution twice daily for 3 consecutive days, followed by a 4-day break. Repeat for up to 4 cycles.

Maximal Weekly Dose: Do not exceed 0.5 mL per treatment session.

Critical Safety Notes

Contraindications: Avoid use during pregnancy, on open wounds, or mucous membranes.

Side Effects: Localized pain, itching, or erythema; discontinue use if severe irritation occurs.

Storage: Keep at 15–25°C, away from light and moisture.


5. Product Specifications & Quality Assurance

Chemical Profile

CAS No.: 518-28-5

Molecular Formula: C22H22O8

Molecular Weight: 414.41 g/mol

EINECS: 208-260-5

Purity: ≥98% (HPLC-verified).

Safety & Compliance Standards

Parameter Standard Testing Method
Pesticide Residues ≤0.01 ppm (USP/EP compliant) GC-MS
Heavy Metals Pb ≤1 ppm, As ≤0.5 ppm, Cd ≤0.2 ppm ICP-MS
Microbial Limits Total plate count ≤100 CFU/g USP <61>
Solvent Residues Meets ICH Q3C Class 2 limits HPLC

6. Sustainable Production & Certifications

GMP Compliance: Manufactured in ISO 9001/ISO 14001-certified facilities.

Certifications: USP, EP, FDA DMF, and WHO PQ listed.

Customization: Available in bulk powder or pre-formulated solutions.


7. Applications Across Industries

Pharmaceuticals: Core ingredient in topical antiviral creams and solutions.

Clinical Dermatology: Used in clinics for in-office wart treatment protocols.

Research: Studied for potential applications in oncology and antiviral therapies.


8. Packaging, Logistics & Support

Packaging: Amber glass vials (1 mL to 100 mL) or bulk pharmaceutical containers.

Shipping: Temperature-controlled global logistics via DHL/FedEx.

Samples: Available for qualified clients upon request.


9. Why Partner with Shaanxi Zhonghong?

Unmatched Purity: HPLC-verified ≥98% purity ensures therapeutic efficacy.

Regulatory Expertise: Full documentation (COA, MSDS, DMF) for seamless market approval.

Global Trust: Preferred supplier to leading pharmaceutical brands in 30+ countries.


10. FAQs

Q1: Is Podofilox safe for self-administration?
No—it must be applied under medical supervision to avoid misuse or overapplication.

Q2: Can it be used on facial warts?
No. It is strictly for external genital and anal warts.

Q3: What is the shelf life?
24 months when stored in unopened original packaging.


11. Conclusion

Shaanxi Zhonghong’s Podofilox (Podophyllotoxin) combines natural sourcing with pharmaceutical precision, offering a reliable solution for HPV-related dermatological conditions. Backed by rigorous quality controls, global certifications, and sustainable practices, it empowers healthcare providers and manufacturers to deliver safe, effective patient care.


References:

United States Pharmacopeia (USP)

European Pharmacopoeia (Ph. Eur.)

Journal of the American Academy of Dermatology.

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