Podofilox

Podophyllotoxin Uses and Synthesis Methods
Introduction
Podophyllotoxin, also known as podophyllotoxin, is a non-alkaloid lignan toxin. It is extracted from the rhizome of podophyllum. Its ethanol solution and ointment are traded under the names of Kangdinglai and Huayudi, respectively, and can be used as topical drugs to treat genital warts caused by human papillomavirus. Podophyllotoxin and its synthetic derivatives such as etoposide and teniposide show a wide range of medical applications such as antiviral and antitumor preparations. Its anticancer activity has been studied to a large extent and used in chemotherapy for lung cancer, lymphoma and reproductive tumors.

Indications
Podophyllotoxin is mainly used to treat genital warts in male or female genitals or anus, and can also be used for other viral warts.
Side effects
Podophyllotoxin often causes burning, pain, and erythema after topical application, and superficial ulcers or erosions may occur after the warts fall off. A small number of male patients will experience obvious edema and erosion in the local area of ​​genital warts around the genitals when using medication.

If you feel any discomfort during the use of the drug, please consult a doctor or pharmacist in time; if the discomfort is severe or not eliminated, please seek medical attention in time.

Contraindications
Podophyllotoxin, also known as podophyllotoxin, is a non-alkaloid lignan toxin. It is extracted from the rhizome of podophyllum. Its ethanol solution and ointment are traded under the names of Kangdinglai and Huayudi, respectively, and can be used as topical drugs to treat genital warts caused by human papillomavirus. Podophyllotoxin and its synthetic derivatives such as etoposide and teniposide show a wide range of medical applications such as antiviral and antitumor preparations. Its anticancer activity has been largely studied and used in chemotherapy of lung cancer, lymphoma and reproductive tumors.

Chemical properties
White needle-shaped crystals, easily soluble in methanol and chloroform, derived from the rhizome of the Berberidaceae plant, the root and stem of the plant Podophyllum of the genus Podophyllum, and the root and stem of the plant Podophyllum of the genus Podophyllum.
Uses
A microtubule assembly and DNA topoisomerase II inhibitor. Podophyllotoxin is a potent inhibitor of microtubule assembly that binds at the colchicine site of tubulin. It is an antineoplastic glucoside and antitumor agent. Also, podophyllotoxin is a Topo II (DNA topoisomerase II) and tubulin inhibitor.
Use
Mainly used for condyloma acuminatum, and can also be used for other viral warts
Use
Inhibit microtubule assembly; anti-tumor. Clinically used for acute monocytic and acute myelomonocytic leukemia, acute myeloid leukemia, chronic eosinophilic leukemia, small cell lung cancer, non-Hodgkin's malignant lymphoma, testicular cancer, etc.