The nutritional components of natto: During the production process, the raw soybean is fermented to break down soy protein, increasing the digestibility of natto from 50% to 85%, making it easier to absorb. Natto has high nutritional value, with higher levels of protein, fiber, calcium, iron, vitamin B, vitamin PP, and vitamin E compared to steamed soybeans. In particular, the content of vitamin B Chemicalbook is more than 6 times higher than that of steamed soybeans. Natto also contains various substances such as protease, multiple vitamins, gamma glutamyl transpeptidase, gamma polyglutamic acid, etc. It also contains highly active substances such as nattokinase, isoflavones, soybean phospholipids, amylase, superoxide dismutase (SOD), saponin, tocopherol, pyridine dicarboxylic acid, vitamin K2, etc.
| Nattokinase Basic information |
| Product Name: |
Nattokinase |
| Synonyms: |
Nattokinase;Nattoesse Haruno-Ogawa;4-(carboxymethyl)-2-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-6-oxo-1,3,2-dioxaborinane-4-carboxylic;Liposomal NATTOKINASE, NATTOKINASE NanoEmulsion, NanoActive NATTOKINASE, Oil-Soluble NATTOKINASE;4-(carboxymethyl)-2-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid;4-(Carboxymethyl)-2-[(1R)-1-{[N-(2,5-dichlorobenzoyl)glycyl]amino}-3-methylbutyl]-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid;Nattokinase (peptidolytic);NattoLife |
| CAS: |
133876-92-3 |
| MF: |
C20H23BCl2N2O9 |
| MW: |
517.12162 |
| EINECS: |
229-880-6 |
| Product Categories: |
133876-92-3 |
| Mol File: |
133876-92-3.mol |
 |
| |
| Nattokinase Chemical Properties |
| form |
Solid |
| color |
White to off-white |
| InChIKey |
YTXSYWAKVMZICI-VVSYKVCONA-N |
| SMILES |
O1C(=O)CC(CC(O)=O)(C(O)=O)OB1[C@@H](NC(CNC(=O)C1=CC(Cl)=CC=C1Cl)=O)CC(C)C |&1:14,r| |
| |
| Nattokinase Usage And Synthesis |
| Chemical Properties |
Nattokinase is an enzyme (a protein that speeds up biochemical reactions) that is extracted from a popular Japanese food called natto. Natto is boiled soybeans that have been fermented with a bacterium called Bacillus natto. |
| Uses |
Although nattokinase is promoted for use as a fibrinolytic and thrombolytic agent, clinical trials are lacking to support such use. There is also no substantial evidence that nattokinase lowers blood pressure in hypertension. |
| Mechanism of action |
Nattokinase decreases the ability of blood to clot. This "thins the blood" and might protect against conditions caused by blood clots such as stroke, heart attack, and others. |
| Side effects |
Small, short-term trials evaluating nattokinase reported no adverse reactions. There is a theoretical risk of bleeding, based on a case report of acute cerebellar hemorrhage in a patient with a history of ischemic stroke. Thrombosis was reported after substitution of nattokinase for warfarin in a patient with a mechanical aortic valve. Rare cases of late-onset anaphylaxis with natto have been attributed to poly-gamma-glutamic acid, a product of the fermentation process that may be present in nattokinase supplements. |
| |
| Nattokinase Preparation Products And Raw materials |
1. Basic dosage of nattokinase
The Japan Nutrition and Health Food Association stipulates that the daily normal maintenance dose of nattokinase should not be less than 2000FU. Therefore, medical nutrition experts suggest that the basic dosage for people taking nattokinase is as follows: 1. A daily intake of 2000FU is recommended for normal or sub healthy individuals to prevent cardiovascular and cerebrovascular diseases. Most people experience physical reactions after taking it for about 7 days, feeling energetic and experiencing improvement in symptoms such as dry eyes; Sensitive individuals responded on the same day. 2. The daily intake is 2000FU-4000FU, which is the recommended dosage for patients with cardiovascular and cerebrovascular diseases. After about 15 days, most of the body will experience positive reactions, such as cold hands and feet, chest tightness and palpitations, limb numbness, dizziness and blurred vision, insomnia and other symptoms gradually improve. After 2-3 months, blood pressure and blood lipid indicators gradually approach normal values, and can be reduced to a healthy maintenance level when the indicators are normal. 3. The daily intake of 4000FU-6000FU is recommended for patients with severe cardiovascular and cerebrovascular diseases. Symptoms begin to slow down after about one month, and the reduction is significant after three months. After the indicators improve, the dosage can be gradually reduced.
2. Contraindications for taking nattokinase
1. Severe diarrhea, vomiting, and indigestion; 2. Patients requiring procoagulant therapy. 3. Patients with bleeding or oozing of skin and internal organs. 4. Those who use high-dose thrombolytic drugs during treatment. 5. After the stent surgery, the population should follow the doctor's advice.
3. The main function of nattokinase
One significant function of nattokinase is its ability to dissolve blood clots. MumuguF et al. used clot lysis analysis to determine the fibrinolytic activity of nattokinase and compared it with Plasmin. They found that the fibrinolytic activity of nattokinase was four times that of Plasmin; MiLsugu．F。 When nattokinase was injected intravenously into a chemically induced thrombus model, significant thrombus dissolution was observed and higher fibrinolytic ability was demonstrated compared to fibrinolytic enzymes and elastase. The above studies indicate that nattokinase exhibits strong fibrinolytic activity both in vitro and in vivo. Nattokinase can also activate fibrinogen in vivo, thereby increasing the amount of endogenous fibrinolytic enzyme. In addition, after taking nattokinase in healthy individuals, the following effects were observed: ① significantly shortened the dissolution time of immunoglobulin (ELT); ② Increased fibrinolytic activity in plasma; ③ The amount of t-PA in plasma has increased. Due to the safety, stability, and good thrombolytic effect of NK, it may be used as an oral reagent for thrombus treatment.
4. Precautions for Nattokinase
Pregnant women are not recommended to consume it, and it should be suspended for 2 weeks before and after surgery to avoid affecting wound healing. Other diseases related to blood clotting must be consulted with a doctor before consumption. If there is significant bleeding, such as vascular rupture, accidents, etc., it should also be avoided from consumption. Patients with cerebral hemorrhage should not consume it until 3 months after the onset of symptoms. Nattokinase belongs to functional foods and cannot replace drugs. Not affected by stomach acid interference, directly absorbed in the small intestine, with a body action time of 8-12 hours. Low calorie, low protein, obese and kidney disease patients can consume it with peace of mind. Eating with medication has no resistance and can reduce adverse reactions of the medication.
_1728976869676.webp)
