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Licochalcone-A
English name Licochalcone-A
English synonyms LICOCHALCONE-A;(E)-3-[5-(1,1-DIMETHYL-2-PROPENYL)-4-HYDROXY-2-METHOXYPHENYL]-1-(4-HYDROXYPHENYL)-2-PROPEN-1-ONE;4′,4-Dihydroxy-3-α,α-dimethylallyl-6-methoxychalcone;2-Propen-1-one, 3-[5-(1,1-dimethyl-2-propen-1-yl)-4-hydroxy-2-methoxyphenyl]-1-(4-hydroxyphenyl)-, (2E)-;(2E)-3-[4-Hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one;7-Dimethoxycoumarin;Licochalcone A, >=98%;Soluble LICOCHALCONE A, Liposomal LICOCHALCONE A, LICOCHALCONE A NanoEmulsion, NanoActive LICOCHALCONE A
CAS No. 58749-22-7
Molecular formula C21H22O4
Molecular weight 338.4
EINECS No. 635-678-2
English synonyms LICOCHALCONE-A;(E)-3-[5-(1,1-DIMETHYL-2-PROPENYL)-4-HYDROXY-2-METHOXYPHENYL]-1-(4-HYDROXYPHENYL)-2-PROPEN-1-ONE;4′,4-Dihydroxy-3-α,α-dimethylallyl-6-methoxychalcone;2-Propen-1-one, 3-[5-(1,1-dimethyl-2-propen-1-yl)-4-hydroxy-2-methoxyphenyl]-1-(4-hydroxyphenyl)-, (2E)-;(2E)-3-[4-Hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one;7-Dimethoxycoumarin;Licochalcone A, >=98%;Soluble LICOCHALCONE A, Liposomal LICOCHALCONE A, LICOCHALCONE A NanoEmulsion, NanoActive LICOCHALCONE A
CAS No. 58749-22-7
Molecular formula C21H22O4
Molecular weight 338.4
EINECS No. 635-678-2
Product Description
[Pharmacological Action] Inhibits tyrosinase, dopachrome interconvertase and DHICA oxidase. In addition to its obvious anti-ulcer, antibacterial and anti-inflammatory, and lipid-lowering effects, licorice flavonoids also have obvious free radical scavenging and antioxidant effects. It is a fast and efficient whitening and freckle-removing cosmetic additive.
Physical properties: yellow needle crystals
Physical properties: antioxidant and anti-carcinogenic effects
References: Chen Yongqiang. Research on the comprehensive development of licorice [D] Sichuan University, 2007.
Sun Mingqian. Research on chemical components in licorice [D] Jilin University, 2006
Product Chinese name: Isoliquiritin
| Product Categories: | The group of Liquorice;sy;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract |
| Mol File: | 58749-22-7.mol |
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| LICOCHALCONE-A Chemical Properties |
| Melting point | 100° |
| Boiling point | 532.6±50.0 °C(Predicted) |
| density | 1.171±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMF:25.0(Max Conc. mg/mL);73.88(Max Conc. mM) DMSO:37.67(Max Conc. mg/mL);111.31(Max Conc. mM) Ethanol:43.5(Max Conc. mg/mL);128.54(Max Conc. mM) |
| pka | 7.82±0.15(Predicted) |
| form | Yellow solid |
| color | Yellow-orange |
| BRN | 4534154 |
| InChIKey | KAZSKMJFUPEHHW-DHZHZOJOSA-N |
| Safety Information |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22 |
| Safety Statements | 36/37 |
| WGK Germany | 3 |
| RTECS | UB8755000 |
| MSDS Information |
| LICOCHALCONE-A Usage And Synthesis |
| Uses | Licochalcone A is an estrogenic flavonoid that induces apoptosis in multiple types of cancer cells. Licochalcone A applied to bone marrow mesenchymal stem cells (BMSC)-aggregate has strong osteogenetic differentiation thus providing a promising strategy in treating osteoporotic weight-bearing bone fractures with defects. |
| Definition | ChEBI: Licochalcone A is a member of chalcones. |
| General Description | An estrogenic flavanoid with anti-tumor and anti-parasitic properties. Shown to reduce Bcl-2 protein expression and induce apoptosis in several human cancer cell lines. Also induces cell differentiation and enhances the effect of paclitaxel and vinblastine chemotherapy. Reported to interfere with parasite mitochondrial electron transport chain and energy metabolism. |
| Biochem/physiol Actions | Inhibits vegetative growth of spore-forming bacteria, B. subtilis and other food-contaminating microorganisms. |
| LICOCHALCONE-A Preparation Products And Raw materials |
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